In Vitro and in Vivo Evaluation of the Antifungal Activity of Apx001a/Apx001 Against Candida
Candida auris is an emerging multidrug-resistant yeast that has been responsible for invasive infections associated with high morbidity and mortality.
Animal Models to Investigate Fungal Biofilm Formation
Microbial biofilms play an essential role in several infectious diseases and are defined as extensive communities of sessile organisms irreversibly associated with a surface, encased within a polysaccharide-rich extracellular matrix (ECM), and exhibiting enhanced resistance to antimicrobial drugs.
A Rabbit Model for Evaluation of Catheter-associated Fungal Biofilms
Most cases of catheter-related bloodstream infections (CRBSIs) involve colonization of micro-organisms on catheter surfaces where they eventually become embedded in a biofilm.
Efficacy of Terbinafine Compared to Lanoconazole and Luliconazole in the Topical Treatment of Dermatophytosis in a Guinea Pig Model
The in vivo efficacy of terbinafine was compared to lanoconazole and luliconazole in the topical treatment of dermatophytosis caused by Trichophyton mentagrophytes using a guinea pig model.
A Murine Model of Contact Lens-associated Fusarium Keratitis
Fusarium solani and F. oxysporum were the causative organisms of the 2005/2006 outbreak of contact lens-associated fungal keratitis in the United States. The present study was an investigation of the ability of F. oxysporum grown as a biofilm on silicone hydrogel contact lenses to induce keratitis.