A Global Leader in Fungal and Bacterial Study
Dr. Ghannoum’s expertise formed the Clinical Research Organization, which created Next-Trillion Science LLC (NTS). The company is designed to assist corporate partners with achieving their R&D objectives for understanding the complex polymicrobial/host interactions related to health and disease.
Our leadership team has the highest level of commitment and collaborates with top hospitals and research centers to develop research.
Dr. Mahmoud A. Ghannoum
Dr. Ghanoum is a world-renowned expert on the microbiome. With more than 25 years of research experience, Dr. Ghannoum has a proven track record of excellence that has attracted more than $25M in federal and $30M in industrial investment.
Years of Research Experience
Million in Industrial Investment
Publications on Microbiology
Dr. Ghannoum has over 300 publications in the field of microbiology, including fungal disease, biofilms, microbiome, drug discovery R&D, and bacterial diseases.
Characterization of the Oral Fungal Microbiome (Mycobiome) in Healthy Individuals
The oral microbiome-organisms residing in the oral cavity and their collective genome-are critical components of health and disease. The fungal component of the oral microbiota
Characterization of Bacterial Communities in Venous Insufficiency Wounds by Use of Conventional Culture and Molecular Diagnostic Methods
To better understand bacterial communities in chronic wounds, we analyzed debridement samples from lower-extremity venous insufficiency ulcers using the following: conventional anaerobic and aerobic bacterial
Oral Mycobiome Analysis of Hiv-infected Patients: Identification of Pichia as an Antagonist of Opportunistic Fungi
Mukherjee PK, Chandra J, Retuerto M, Sikaroodi M, Brown RE, Jurevic R, Salata RA, Lederman MM, Gillevet PM, Ghannoum MA. PLoS Pathog. 2014 Mar 13;10(3):e1003996.PLoS
With our own laboratory, we can dive deep into maintaining health and treating illness.
Microbial and Fungal Biofilms
Microbial and fungal biofilms have been targeted as the most significant problem-preventing antifungal and antibacterial drugs, and they have been recently linked to the microbiome while targeting specific functions occupied in the organs, such as the gut.
Dr. Ghannoum’s leading-edge research deeply investigates microbial and fungal biofilms. In fact, he was the first investigator to coin the term “mycobiome” since a portion of his research focused closely on the neglected fungal side of the microbiome equation. He even wrote the book Microbial Biofilms.
To build upon his research, Dr. Ghannoum has collaborated with numerous pharmaceutical companies, developing tailored in vitro (referencing the Clinical and Laboratory Standards Institute) and in vivo (murine, rabbit, guinea pigs, etc.) examines. They were designed to test antibacterial and antifungal drug efficacy.
Cutting-Edge Sequencing Technology
Dr. Ghannoum’s laboratory has focused on the use of cutting-edge sequencing technology for analysis of the bacterial microbiome 16S and fungal mycobiome ITS in order to characterize the bacterial and fungal communities that reside in different parts of the body, including the gut, oral cavity, skin, and reproductive system.