As a global leader in human microbiota research, it’s no wonder Next-Trillion Science LLC (NTS) is approached by many companies to help with developing their R&D. By understanding the complex polymicrobial/host interactions related to health and disease, NTS is well-positioned to develop therapeutics for rebalancing the microbiome.
NTS is the first company to interrogate inter-kingdom interactions as a means of identifying actionable steps that will lead to the discovery of novel therapeutic, probiotic, and nutritional approaches. This is what helps NTS to harmonize the microbiota for maintaining health and treating illness.
With a list of services related to human microbiota research, NTS can help with designing interventional therapeutic tools that harmonize the microbiota.
Founder, Dr. Mahmoud Ghannoum
Our Microbiome Services
With a list of services related to human microbiota research, NTS can help with designing interventional therapeutic tools that harmonize the microbiota.
Micro- and Myco-biome Transcriptomics
Microbiome (fungal and bacterial) profiling compares the microbiota in various healthy and diseased conditions.
Microbial Proteomics and Metabolomics
Assessment of metabolome associated with microbiome analysis (tissue, stool, or culture models) and determining the identification of bacterial or fungal metabolites.
Microbial Bioinformatics and Computational Biology
A standardized operating procedure workflow which allows for demultiplexing and classification and bioinformatic filtering of the sequence data.
Microbial Biorepository and Cultivation Facilities
NTS partners with the Center for Medical Mycology to offer in vitro models of Candida biofilms to characterize formation on clinically relevant medical devices.
Vertebrate Animal Testing
NTS collaborates with the Center for Medical Mycology preclinical modeling core to offer several small animal models for fungal/bacterial infection/disease.
Advanced Microbial Imaging
Investigative advanced capabilities in microbial and fungal imaging using transmission and scanning electron microscopy.
Interventional Core Services
Custom design and work with sponsors interested in promoting human health and combating disease.
News & Media
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Characterization of the Oral Fungal Microbiome (Mycobiome) in Healthy Individuals
The oral microbiome-organisms residing in the oral cavity and their collective genome-are critical components of health and disease. The fungal component of the oral microbiota has not been characterized. In this study, we used a novel multitag pyrosequencing approach to characterize fungi present in the oral cavity of 20 healthy individuals, using the pan-fungal internal transcribed spacer (ITS) primers. Our results revealed the "basal" oral mycobiome profile of the enrolled individuals, and showed that across all
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Characterization of Bacterial Communities in Venous Insufficiency Wounds by Use of Conventional Culture and Molecular Diagnostic Methods
To better understand bacterial communities in chronic wounds, we analyzed debridement samples from lower-extremity venous insufficiency ulcers using the following: conventional anaerobic and aerobic bacterial cultures; the Ibis T5000 universal biosensor (Abbott Molecular); and 16S 454 FLX titanium series pyrosequencing (Roche).
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Oral Mycobiome Analysis of Hiv-infected Patients: Identification of Pichia as an Antagonist of Opportunistic Fungi
Mukherjee PK, Chandra J, Retuerto M, Sikaroodi M, Brown RE, Jurevic R, Salata RA, Lederman MM, Gillevet PM, Ghannoum MA. PLoS Pathog. 2014 Mar 13;10(3):e1003996.PLoS Pathog. 2010 Jan 8;6(1):e1000713.
Events
Next-Trillion Science LLC (NTS) is asked to speak and attend a variety of events all over the world. We educate with our leading-edge research on microbial and fungal biofilms.
With a laboratory focused on cutting-edge sequencing technology for analysis of the bacterial microbiome 16S and fungal mycobiome ITS, NTS can dive deep into maintaining health and treating illness.
Our Clients
