NTS collaborates with the Center for Medical Mycology preclinical modeling core to offer several small animal models for fungal/bacterial infection/disease, as well as unique in vivo models of biofilm formation – rabbit indwelling catheter model and a murine model of contact lens-associated fungal infection.
This characterizes biofilm formation on contact lenses in vitro and examines the effect of biofilm on contact lens-associated fungal infection in vivo. NTS also offers a proprietary guinea pig model of dermatophytosis. Directly related to the microbiome, NTS offers murine models designed to evaluate the effect of drugs directly on the micro- and myco-biome of the gut (e.g., DSS-induced colitis model).
NTS can assist investigators to establish in vivo small animal models (mouse, guinea pig, rabbit, rat) of fungal or bacterial infection to use as preclinical models.
This capability is especially useful for corporate partners interested in designing experimental models that can be adapted to drug or small molecule testing for generation of preliminary in vivo data.
Fusarium solani and F. oxysporum were the causative organisms of the 2005/2006 outbreak of contact lens-associated fungal keratitis in the United States. The present study was an investigation of the ability of F. oxysporum grown as a biofilm on silicone hydrogel contact lenses to induce keratitis.
Efficacy of Terbinafine Compared to Lanoconazole and Luliconazole in the Topical Treatment of Dermatophytosis in a Guinea Pig Model
The in vivo efficacy of terbinafine was compared to lanoconazole and luliconazole in the topical treatment of dermatophytosis caused by Trichophyton mentagrophytes using a guinea pig model.
Most cases of catheter-related bloodstream infections (CRBSIs) involve colonization of micro-organisms on catheter surfaces where they eventually become embedded in a biofilm.
Microbial biofilms play an essential role in several infectious diseases and are defined as extensive communities of sessile organisms irreversibly associated with a surface, encased within a polysaccharide-rich extracellular matrix (ECM), and exhibiting enhanced resistance to antimicrobial drugs.
Candida auris is an emerging multidrug-resistant yeast that has been responsible for invasive infections associated with high morbidity and mortality.